Your 6-year-old mixed breed, Buddy, had routine bloodwork at his annual exam. The vet called: "His liver values are a bit elevated. Nothing alarming, but we should follow up." You have the printed results. ALT: 280 (reference 10-125). ALP: 220 (reference 23-212). Everything else looks normal. What does this mean?
Routine bloodwork typically includes a CBC (complete blood count)—red cells, white cells, platelets—and a chemistry panel—organ function and electrolytes. For Buddy, the CBC is normal. On the chemistry, the liver enzymes stand out. ALT (alanine aminotransferase) is found primarily in hepatocytes; elevation suggests hepatocellular injury. ALP (alkaline phosphatase) is found in liver, bone, intestine, and placenta; elevation can indicate cholestasis, hepatic injury, or even bone growth (in young dogs).
The Bloodwork OCR lets you upload a photo of the lab report. The AI parses the values and provides an educational explanation—helpful for understanding before your follow-up visit.
ALT is relatively liver-specific. Elevation suggests liver cell damage—from inflammation, toxins, infection, or metabolic disease. ALP can be elevated from liver (cholestasis, drug induction), bone (growth, disease), or other sources. Corticosteroids induce ALP in dogs (steroid ALP). Mild to moderate elevations may be incidental (e.g., after a recent meal, stress) or may indicate early disease. The pattern and magnitude guide next steps.
The Internal Medicine Specialist discusses differentials for elevated liver enzymes: Hepatitis (infectious, immune-mediated, idiopathic), hepatic lipidosis, portosystemic shunt, neoplasia, drug-induced (e.g., phenobarbital, NSAIDs), or extrahepatic (Cushing's, hypothyroidism, pancreatitis). History, physical exam, and additional testing narrow the list.
To assess liver function (not just enzyme leakage), fasting and post-prandial bile acids are often recommended. Bile acids test the liver's ability to process and recirculate bile—abnormal values suggest dysfunction. Abdominal ultrasound evaluates liver size, echogenicity, and architecture; it can identify masses, nodules, or vascular anomalies. In some cases, a liver biopsy is needed for definitive diagnosis.
The General Vet AI suggests questions to ask: "What could be causing these elevations?" "Do we need more tests, and which ones?" "Is this urgent or can we monitor?" "Are there any medications or supplements that could affect these values?" Bring the lab report, note any symptoms (lethargy, vomiting, appetite changes), and list all medications and supplements. PetMed AI tools support education—they do not replace veterinary diagnosis or treatment decisions.
Use Bloodwork OCR to upload lab reports for AI-parsed explanation, and the Internal Medicine Specialist for hepatic differential discussion.
- ALT indicates hepatocellular injury; ALP can reflect liver, bone, or drug effects.
- Mild elevations may be incidental or early disease—follow-up is important.
- Bile acids and ultrasound are common next steps for persistent elevation.
- Bloodwork OCR helps you understand the numbers—discuss interpretation with your vet.
- Bring your questions to the follow-up visit. Your vet will tailor the plan to your dog.