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My Dog's Leg Looks Swollen After a Tick Bite — Lyme Disease?

A 5-year-old Golden Retriever with limping and swollen joint after tick exposure. Lyme disease causes arthritis; testing and treatment are straightforward.

8 min read2026-01-29
Lyme diseasetick bitedog limpingtick-borne
PetMed AI Veterinary TeamVerified

Reviewed by Licensed DVM Professionals

Evidence-BasedPeer-Reviewed SourcesLast updated: 2026-01-29
Case Presentation

Your 5-year-old Golden Retriever, Sunny, has been limping for 3 days. One leg is swollen at the joint. You removed a tick from him last week after a hike. Could it be Lyme disease?

5 yr
Age
Golden Retriever
Breed
1 wk ago
Tick Exposure
Swollen joint
Limping

🩺 Lyme Disease in Dogs

Borrelia burgdorferi is transmitted by Ixodes ticks. Clinical signs include fever, lethargy, lymphadenopathy, and shifting leg lameness (arthritis). The Parasitology Specialist explains: Tick exposure + lameness + swollen joint = consider Lyme. 4Dx or C6 test confirms. The Bloodwork OCR helps interpret C6 antibody results.

💊 Treatment

Doxycycline for 28–30 days at 5–10 mg/kg BID. The Internal Medicine Specialist outlines dosing. Response is typically rapid—lameness improves within 24–48 hours. Positive C6 without clinical signs may not require treatment (exposure vs disease). Nephritis (Lyme nephritis) is rare but serious—monitor kidney values in positive dogs.

Use Bloodwork OCR, Internal Medicine Specialist, and Parasitology Specialist for Lyme workup and treatment.


Key Takeaways
  • Tick exposure + lameness = consider Lyme disease.
  • C6 or 4Dx test confirms exposure/antibodies.
  • Doxycycline 28–30 days—standard treatment.
  • Rapid response—lameness improves quickly with treatment.
  • Tick prevention reduces risk—use year-round in endemic areas.

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